Neurology Updates

Here you will find regular scientific news from our scientific panels. We cover all areas of neurology, including rare diseases. The latter will be particularly marked and are also available via the Center of Rare Diseases. The most recent news are displayed below. You will find all news of different areas sorted into the subsections of the respective scientific panel. Enjoy reading!

If you want to submit a neurology update for your scientific panel, please login and download the form here.

Scientific Panels

Detailed information about the organization of, members and structure of EAN scientific panels can be found here. 

| Epilepsy

Status epilepticus (SE) remains life thereatening condition with limited therepautic options. Benzodiazepine-refractory, or established, SE is thought…

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| Palliative Care

A new guideline on the palliative care for people with severe multiple sclerosis has been produced by EAN, in collaboration with the European…

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| Epilepsy

A double-blind, randomised, placebo-controlled phase II study of adjunctive cenobamate in adults with uncontrolled focal epilepsy showed high rates of…

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| COVID-19

Rare neurological diseases are usually hereditary chronic disorders, affecting the central, peripheral nervous system and skeletal muscle, with…

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| COVID-19

This neurology update summarises key points on caring for people with epilepsy during the COVID-19 pandemic.

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| COVID-19

Seizures appear to be a rare feature of COVID-19. Avoiding unintentional antiseizure medicine withdrawal during the COVID-19 pandemic is a potential…

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| COVID-19

According to the WHO, the spread of coronavirus disease 2019 (COVID-19) has already reached pandemic proportion, affecting at present more than…

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| COVID-19

The ongoing COVID-19 outbreak raises new management challenges, which lack an evidence-based answer to date. The management group of the EAN…

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| COVID-19

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with…

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| COVID-19

The number of subjects infected with SARS-Cov-2 is dramatically increasing worldwide since the beginning of this year.

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| COVID-19

The SARS-CoV-2/COVID-19 pandemic is deeply affecting our health systems both directly and indirectly. In several countries, neurorehabilitation units…

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| COVID-19

In view of the challenges of the current Corona virus (COVID-19) pandemic and with the aim of protecting both patients and ultrasound providers…

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| COVID-19

At present, the Covid-19 pandemic is the focus of the global community and an all-consuming threat to the health care systems all across Europe.…

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| COVID-19

We are experiencing an unprecedented situation that no one had imagined or prepared for which has hit Europe during a period of prosperity, and the…

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| COVID-19

The growing emergency due to the Covid-19 pandemic has rapidly and abruptly stressed health systems in all involved countries. Post-acute…

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| COVID-19

The authors of this review (2) article hypothesize that respiratory dysfunction could be explained in part by the well-known neuroinvasive potential…

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| Clinical neurophysiology

Cutaneous silent period is a useful, although underestimated tool for the clinical assessment of poly neuropathy as well as other neurological…

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| COVID-19

The Covid-19 global pandemic is having a dramatic impact on many chronic conditions including those affecting neurological patients and among them…

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| COVID-19

Due to the CoVID-19 pandemic spread, most outpatient facilities have been strictly regulated, thus making it difficult for many patients suffering…

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| COVID-19

Neuromuscular diseases are a group of heterogenic rare conditions, that can be due to a genetic cause, inflammatory processes or dysimmune disorders.…

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| COVID-19

Highly pathogenic coronavirus infections are well-established sources of previous epidemics (severe acute respiratory syndrome coronavirus: SARS‐CoV,…

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| COVID-19

In patients with Amyotrophic Lateral Sclerosis (ALS), the impact of respiratory infections is expected to be more serious than in the general…

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| COVID-19

Coronavirus Disease 2019 (COVID-19) typically causes fever, pulmonary and respiratory symptoms as well as gastrointestinal symptoms in the form of…

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| COVID-19

During the Covid-19 pandemic, most European countries have imposed personal restrictions on their populations in order to inhibit viral transmission…

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| COVID-19

To our knowledge, there is currently no evidence on how and if Corona Virus Disease 2019 (COVID-19) affects people with rare neurological diseases,…

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| COVID-19

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus causes…

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| COVID-19

Physicians of all specialties worldwide are challenged by the new SARS-CoV-2 virus causing corona virus disease 2019 (COVID-19). The virus is causing…

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| COVID-19

An unexpected outbreak due to the infection by the coronavirus, Covid-19, which started in China at the end of 2019, is rapidly expanding and is now…

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| COVID-19

Corona Virus Disease 2019 (COVID-19) is a new illness caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),…

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| Neuro-oncology

Practice changing studies have been published in late 2017 and 2018 on IDH wild-type diffuse astrocytoma (the new entity of WHO 2016 classification),…

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| Neurotraumatology

Patients with mild to moderate traumatic brain injury may benefit from treatment with Tranexamic Acid within 3 hours of injury.

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| Autonomic nervous system disorders

Can physiotherapy combined with vagal nerve stimulation enhance the functional recovery after stroke?

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| Neurogenetics

A recent paper from Cortese et al (2019) reported that a new intronic expansion may be a relevant cause of late-onset ataxia.

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| Autonomic nervous system disorders

Multiple system atrophy (MSA) is a rare, fatal, neurodegenerative disease of the adulthood presenting with progressive autonomic failure,…

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| Neurotoxicology

A patient with Nakalanga syndrome (NLS) is unlikely to present for clinical care in Europe because cases are confined to impoverished sub-Saharan…

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| Sleep disorders

Findings suggest narcolepsy type 1 to be a T-cell mediated autoimmune disease targeting hypocretin-producing Neurons.

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| Epilepsy

There are limited options as second line treatment in convulsive status epilepticus (CSE), both in underage and adult populations with sufficient…

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| Infectious diseases

Zika virus circulation has decreased but there is a possibility of its emergence or re-emergence in all areas with competent mosquito vectors.

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| Epilepsy

In patient with post stroke epilepsy and non-valvular atrial fibrillation, the combination of levetiracetam and NOACs is very valuable. Therapeutic…

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| Neuropathies

Antiparanodal antibodies in CIDP.

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| Neuropathies

No benefit from second dose of immunoglobulin treatment for severe Guillain-Barre syndrome.

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| Higher Cortical Functions

Right frontal regions make a significant contribution to inhibitory behavioural control.

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| Infectious diseases

Fluoroquinolones increase the risk of peripheral neuropathy.

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| Palliative Care

Neurology and Palliative Care - collaboration now and in the future

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| Sleep disorders

Multimodal neuroimaging studies highlight the extent brain-wide structural changes in narcolepsy type 1.

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| Clinical neurophysiology

Guidelines based on consensus of international experts on the current status of Single Fiber EMG and the measurement of neuromuscular jitter with…

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| Clinical neurophysiology

The first IFCN-endorsed clinical guidelines for magnetoencephalography

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| Coma & Chronic Disorders of Consciousness

Three patients with chronic disorders of consciousness showed behavioural and neuroimaging improvements after 30 days of treatment by apomorphine in…

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| Clinical neurophysiology

Guidelines based on consensus of international experts on the current status of Single Fiber EMG and the measurement of neuromuscular jitter with…

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| Clinical neurophysiology

The first IFCN-endorsed clinical guidelines for magnetoencephalography

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| Coma & Chronic Disorders of Consciousness

Three patients with chronic disorders of consciousness showed behavioural and neuroimaging improvements after 30 days of treatment by apomorphine in…

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| Epilepsy

There is need for automated seizure detection using wearable devices, to decrease the morbidity and mortality associated with seizures, especially…

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| Neurosonology

Transcranial sonography and MRI - fusion ultrasound can serve as a screening tool for detecting the preclinical stage and differential diagnosis of…

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| Stroke

Intravenous thrombolysis improved outcomes in ischemic stroke patients between 4.5-9 hours after symptom onset based on perfusion Imaging.

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| Muscle & Neuromuscular Junction Disorders

An integrated approach, merging accurate genetic and clinical data, is critical to properly study the effect of new treatments in FSHD.

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| Neurogenetics

DNA methylation editing of the FMR1 gene rescue Fragile X syndrome neurons.

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| Neuro-ophthalmology and -otology

Awareness of atypical features in optic neuritis is crucial to initiate appropriate treatment and prevent permanent visual loss.

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| Pain

Whether small fiber pathology accounts for pain in fibromyalgia, and whether brain imaging can be used as an objective marker of pain remain…

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| Neurorehabilitation

An article from the February 2019 edition of Neuropharmacology published by researchers from the Department of Physical Medicine & Rehabilitation from…

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| Child neurology

A major issue in genetic disorders is to find out clues, which may help to interpret the phenotypic heterogeneity, in order to provide more precise…

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| Coordinating Panel on Rare Neurological Diseases

Anectdotal evidence has pointed out clinical improvements narcolepsy-specific symptoms following treatment of painful conditions with opiates.…

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| Infectious diseases

One of the most controversial topics in microbiome research is the connection between the gut microbial metabolism and mental health. Advanced…

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| Higher Cortical Functions

Up to 20% of patients with Parkinson's disease (PD) develop impulse control behaviours (ICBs) on dopaminergic therapy, particularly on dopamine…

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| Infectious diseases

Nodding syndrome (NS) is a neurologic disorder of unknown cause that affects children in the subsistence-farming communities of East Africa.…

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| Clinical neurophysiology

To date there is no electrophysiological gold standard in defining the subtypes of GBS. Recovery of abnormal CMAP amplitude reduction and of…

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| Clinical neurophysiology

Somatosensory evoked potentials (SEPs) allow to obtain functional and localising information about the dorsal somatosensory system. SEPs are…

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| Epilepsy

Epilepsies affect around 65 million people worldwide and are clinically a heterogeneous group of neurological disorders. Despite strong evidence for…

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| Neurotraumatology

A subset of mild traumatic brain injury (mTBI) patients experience post-concussion symptoms. When a cluster of post-concussion symptoms persists for…

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| Autonomic nervous system disorders

Pure autonomic failure (PAF) is both, a rare condition and a pathogenetic mystery, first described by Bradbury and Eggleston in 1925, as a syndrome…

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| Palliative Care

The use of tracheostomy with invasive ventilation (TIV) for amyotrophic lateral sclerosis (ALS) is challenging and raises the most delicate questions…

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| Dementia and cognitive disorders

Despite its large use, recommendations for the use of brain F-18 FDG-PET in clinical practice were still lacking. The European Academy of Neurology…

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| Multiple Sclerosis

Among the different environmental variables that may play a role in the pathogenesis of MS, the influence of the microorganisms living in or on the…

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| Autonomic nervous system disorders

Functional gastrointestinal disturbances affect the vast majority of Parkinson’s Disease (PD) patients before appearance of the cardinal motor…

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| Movement Disorders

Differential diagnosis of tremor syndromes is challenging task for neurologists. The need of a new classification scheme arises from recent…

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| Stroke

Recently two trials reported results about effectiveness of thrombectomy for patients with acute ischemic stroke with large-vessel occlusion of…

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| Coma & Chronic Disorders of Consciousness

Behavioural scales, such as the Coma Recovery Scale-Revised (CRS-R), are universally considered the gold standard for responsiveness assessment,…

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| Headache

The last months saw the publication of large clinical trials on the efficacy of CGRP antibodies in chronic migraine. This offers a new perspective for…

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| Neurocritical care

Heparin-induced thrombocytopenia (HIT) is a rare but very important condition characterized by a sudden decrease in the platelet count of more than…

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| Neurotoxicology

Although smoking is associated with a more severe disease course in people with multiple sclerosis (MS), the magnitude of effect of smoking cessation…

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| ALS and frontotemporal dementia

It was l suggested a long time ago, that ALS is rather a cortical than a spinal disease. The work of Heiko Braak and collaborators has demonstrated…

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| Palliative Care

There are increasing close links between palliative care and neurology.  The European Association for Palliative Care has a close relationship with…

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| Neuroimmunology

Antibodies to leucine-rich glioma-inactivated 1 (LGI1) are associated with faciobrachial dystonic seizures (FBDS) and limbic encephalitis. Although…

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| Coordinating Panel on Rare Neurological Diseases

Classical trigeminal neuralgia is a rare painful chronic disorder. Carbamazepine and oxcarbazepine are first line treatments and act by blocking…

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| Muscle & Neuromuscular Junction Disorders

Dear colleagues, 

we would like to drive your attention to the recent developments in Spinal Muscular Atrophy. Two different approaches (use of…

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| Neurogenetics

McNeill and colleagues describe a patient suffering from leukoencephalopathy, brain calcifications and cysts (LCC).

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| Neuroepidemiology

The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides information on the worldwide and country-specific distribution, trends…

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| Coordinating Panel on Rare Neurological Diseases

In the past years multiple publications have focused on the immunological etiology of narcolepsy. Despite the extremely tight association with HLA…

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| Neurotraumatology

According to current guidelines [1] by the Brain Trauma Foundation in traumatic brain injury (TBI), intracranial pressure monitoring (ICP) is still…

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| Neurorehabilitation

Recently, a meta-analysis was published indicating  a beneficial effect of Cerebrolysin, a multimodal molecule, in the early rehabilitation of…

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| Neuro-oncology

Several key papers regarding advances in brain tumors have been published in 2016 and 2017, and all are practice changing. A pivotal European/Canadian…

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| Neuropathies

Hereditary transthyretin (TTR) amyloidosis (hATTR) is a devastating, progressive and ultimately fatal genetic disease with limited treatment…

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| Autonomic nervous system disorders

The principal autonomic neurotransmitters, acetylcholine and noradrenaline, are involved in immune regulation in the context of inflammation through…

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| Higher Cortical Functions

This important study is the first to present neuroanatomical evidence for transneuronal damage to functional homologues of the attention  network in…

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| Headache

On 21 March 2017, several activities including a meeting in the European Parliament were organized. In addition, the European Headache Alliance have…

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| Stroke

In the setting of haemorrhagic stroke, presence of intraventricular haemorrhage is a hallmark of poor prognosis with case-fatality up to 60%.1,2 Data…

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| Coordinating Panel on Rare Neurological Diseases

On 28th February, the world celebrates the Rare Disease Day 2017, sponsored by Eurordis.

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| Palliative Care

Over the past few years the Taskforce of the European Association for Palliative Care (EAPC) on neurology has been working on the writing of a…

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| Stroke

The results of previous randomized trials, especially INTERACT-2, have shown that early intensive blood pressure lowering in patients with spontaneous…

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| Neurosonology

Lochner et al. reported on the diagnostic applicability of ultrasonography in idiopathic intracranial hypertension (IH) or secondary intracranial…

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| Neurosonology

Viski et al. reported on the effect of reading on blood flow changes in the posterior cerebral artery in early blind and sighted people using TCD.

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| Neurosonology

Favaretto et al. explored in this study the diagnostic role of transcranial brain parenchyma sonography in detecting specific echogenic alterations of…

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| Neurosonology

Rouco et al. present a new method that may improve the performance of previous approaches for the automatic detection of the common carotid artery…

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| Neurosonology

Perren et al. compared in this study the diagnostic sensitivity of transcranial color-coded duplex (TCCD) sonography and the recently developed 3D…

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| Neurosonology

Kargiotis et al. present their preliminary observations of consecutive ultrasound evaluations in 2 patients with acute encephalitis (presenting with…

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| Stroke

The Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) was driven by concerns about safety of intravenous alteplase in terms…

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| Stroke

The International normalized ratio (INR) normalization in Coumadin-induced intracerebral haemorrhage (INCH) trial compared the effect of intravenous 4…

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| Autonomic nervous system disorders

Faint or Syncope is the sudden loss of consciousness, associated with the inability to maintain postural tone followed by the immediate, spontaneous…

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| Stroke

The multicentre, randomized-controlled Platelet Transfusion in Cerebral Haemorrhage (PATCH) study tested whether platelet transfusion could be…

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| Movement Disorders

A Task Force was created by the International Parkinson and Movement Disorders Society in 2012 with the aim of analyzing apparent problems and…

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| Neurotoxicology

This is a significant clinical-epidemiological 2001-2013 survey of neurodegenerative disease among the Auyu and Jaqai linguistic groups of Papua,…

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| Stroke

In 2015 acute stroke therapy has taken an important step forward with a series of trials which have shown a better functional outcome of patients with…

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| Neurosonology

1. Fibular nerve palsy after hip replacement: Not only surgeon responsibility. Hereditary neuropathy with liability to pressure palsies (HNPP) a rare…

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| Dementia and cognitive disorders

A recent study published in Journal of Alzheimer's Disease has found that most, but not all, patients in Sweden diagnosed with dementia have their…

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| Neurosonology

This retrospective study coming from Sands et al. highlights the incidence of acute isolated central facial palsy as manifestation of Middle Cerebral…

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| Infectious diseases

Late Breaking News

Zika is a viral disease transmitted by Aedes Mosquitoes. There are multiple neurologic manifestationsof this condition. The South American epidemic…

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| Neuroimmunology

The progress made over the past 15 years in the field of autoimmune encephalitis has transformed the diagnostic approach to these disorders and led to…

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| Neuroimaging

The following updates were focused specifically on clinically relevant neuroimaging studies in patients with Parkinson’s disease and in migraine…

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| Stroke

In 2015 acute stroke therapy has taken an important step forward with a series of trials which have shown a better functional outcome of patients with…

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| Palliative Care

The Palliative Care Scientific Panel aims to encourage the development of palliative care for people with neurological disease.  There are increasing…

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| Neuro-ophthalmology and -otology

Isolated ocular myasthenia gravis is often a diagnostic challenge, as most common ancillary tests, such as acetylcholine receptor autoantibodies and…

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| Epilepsy

Brivaracetam was approved for adjunctive treatment of partial epilepsy with focal and secondary generalised seizures by the EMEA in January 2016.…

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| ALS and frontotemporal dementia

In this work the therapeutic value of a diaphragm pacemaker  is examined on a trial in patients with amyothropic lateral sclerosis. Patients underwent…

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| ALS and frontotemporal dementia

The current diagnostic criteria for ALS, the El Escorial Criteria, have met with criticism by the community (Agosta F, Al-Chalabi AFilippi MHardim…

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| Muscle & Neuromuscular Junction Disorders

The use of statins in neurocardiovascular conditions has widely increased over the decades. Based on extension of indications major side effects of…

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| Coma & Chronic Disorders of Consciousness

In the last decade, patients clinically diagnosed in the vegetative state who are able to perform mental imagery tasks [1-2] have been still…

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| Coordinating Panel on Rare Neurological Diseases

Advances in understanding memory mechanisms have crucial implications for cognitive neurology, and it is very good news that current studies combining…

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| Coordinating Panel on Rare Neurological Diseases

Searching for early biomarkers for alpha synucleinopathies, a recent study by Drahms et al. revealed that cardiac/vascular dysfunction in prodromal…

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| Coordinating Panel on Rare Neurological Diseases

Syncope is a frequent clinical presentation in neurology departments. This clinical event, situated at the border between neurology and cardiology, is…

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| Autonomic nervous system disorders

Searching for early biomarkers for alpha synucleinopathies, a recent study by Drahms et al. revealed that cardiac/vascular dysfunction in prodromal α-…

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