Neurology Updates

TK2 deficiency is a rare mitochondrial disorder with a broader clinical spectrum than previously recognized, affecting children and adults. The…

Plasma periaxin is an ultrasensitive biomarker that differentiates peripheral demyelinating neuropathies from CNS diseases. A 2025 Brain study…

A cross-sectional study of sural nerve biopsies in chronic inflammatory demyelinating polyneuropathy (CIDP) showed extensive deposition of terminal…

Cemdisiran, a small interfering RNA (siRNA) that targets complement C5 mRNA and is administered subcutaneously, demonstrated efficacy in the treatment…

Phase 2/3 DEVOTE trial reached the primary endpoint, which is improvement in the CHOP INTEND score in the 50/28 mg nusinersen regimen compared with…

Recessive RNU2-2 syndrome is a highly prevalent neurodevelopmental disorder characterized by severe developmental delay, epilepsy, and overlap with…

Piet et al. propose a new paradigm: epilepsy risk and phenotype are determined by the combined effects of rare high-impact variants and the polygenic…

Delpacibart etedesiran, a monoclonal antibody–oligonucleotide conjugate, showed delivery to muscle and improvement of aberrant splicing in patients…

EMA has recommended granting a marketing authorisation in the European Union for Levacetylleucine for the treatment of neurological manifestations in…

This study by Kumar et al. explores the neural circuits underlying cognitive dysfunction in spinocerebellar ataxia type 2 (SCA2), an inherited…

Stiff Person Syndrome (SPS) is an autoimmune neurological disorder marked by rigidity, spasms, and heightened sensitivity to stimuli, often associated…

Recent decade brought major developments in MG. Five new things highlighted include thymectomy, new immunotherapies, recent guidelines, progress in…