Registrar's Reading Lists
Scientific Panels Submissions
Registrar's Reading Lists
For many neurological conditions there are guidelines and expert statements available. Journals focus on trainees teaching topics (e.g. practical neurology). Furthermore, there are many reviews on clinical issues of variable quality.
The aim is to build a reading list of high-quality and up-to-date reviews on core neurology curriculum areas for registrars across Europe. The focus should be clinical and practical, to guide neurology trainees learning their trade in optimal standards of diagnosis, investigation and management in daily clinical practice.
You can find below a list of reviews, recommended by the EAN Scientific Panels.
EAN Scientific Panels
| Bedside Approach to Autonomic Disorders? A clinical Tutor | Edited by Walter Struhal, Heinz Lahrmann, Alessandra Fanciulli and Gregor K.Wenning | Springer Verlag, 2017. | Download |
| Multiple System Atrophy | Edited by Gregor K. Wenning & Alessandra Fanciulli | Springer Verlag, 2014. | Download |
| Primer of the Autonomic Nervous System | Robertson D, Biaggioni I, Burnstock G, Low PA, Paton JFR, eds | Academic Press, Oxford, 2012 | Download |
| Clinical Autonomic Disorders,Low PA | Benarroch EE, eds.: Clinical Autonomic Disorders, | Third Edition. Lippincott Williams & Wilkins, Philadelphia, 2008 | Download |
| Neurourology: Theory and Practice. | Editors: Liao, Limin, Madersbacher, Helmut (Eds.) | Springer 2019 | Download |
| Standards for quantification of EMG and neurography | Stålberg E, van Dijk H, Falck B, Kimura J, Neuwirth C, Pitt M, Podnar S, Rubin DI, Rutkove S, Sanders DB, Sonoo M, Tankisi H, Zwarts M | Clinical Neurophysiology 2019, Issue 19 | Download |
| Fasciculation; Amyotrophic lateral sclerosis; benign fasciculation syndrome | Mamede de Carvalho; Matthew Kiernan; Michael Swash | Journal of Neurology, Neurosurgery and Psychiatry 2017, Issue 88 | Download |
| Current status on electrodiagnostic standards and guidelines in neuromuscular disorders | Anders Fuglsang-Friederiksen; Kirsten Pugdahl | Clinical Neurophysiology 2011, Issue 122 | Download |
| The Role of Nerve Conduction Studies, Quantitative Sensory Testing, and Autonomic Function Testing | RK Olney: Clinical Trials for Polyneuropathy | Journal of clinical neurophysiology 1998, Issue 15 | Download |
| Facial nerve palsy and hemifacial spasm | Josep Valls-Sole | Handbook of clinical neurophysiology 2013, Issue 115 | Download |
| Why and When to Refer Patients for Vestibular Evoked Myogenic Potentials: A Critical Review | Papathanasiou ES, Straumann D | Clin Neurophysiol 2019;130:1539-1556 | Download |
| Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS) | Jean-Pascal Lefaucheur, Andrea Antal, Samar S. Ayache, David H. Benninger, Jérôme Brunelin, Filippo Cogiamanian, Maria Cotelli, Dirk De Ridder, Roberta Ferrucci, Berthold Langguth, Paola Marangolo, Veit Mylius, Michael A. Nitsche, Frank Padberg, Ulrich Palm, Emmanuel Poulet, Alberto Priori, Simone Rossi, Martin Schecklmann, Sven Vanneste, Ulf Ziemann, Luis Garcia-Larrea, Walter Paulus | Clinical Neurophysiology 2017, Issue 128 (1) | Download |
Dementia and Cognitive Disorders
Subjective cognitive decline (SCD)
Alzheimer´s disease (AD)
Mild cognitive impairment due to AD (MCI)
AD dementia
NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease.
Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers.
AD dementia treatment
A European Academy of Neurology guideline on medical management issues in dementia.
Current understanding of Alzheimer's disease diagnosis and treatment.
Treatment Combinations for Alzheimer's Disease: Current and Future Pharmacotherapy Options.
Management of mild cognitive impairment (MCI): The need for national and international guidelines.
Atypical forms of AD
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria.
Posterior cortical atrophy
Frontal variant AD
Diagnosing the frontal variant of Alzheimer's disease: a clinician's yellow brick road.
Logopenic aphasia
Classification of primary progressive aphasia and its variants.
Differential diagnosis of dementia
EFNS-ENS Guidelines on the diagnosis and management of disorders associated with dementia.
Consensus guidelines for lumbar puncture in patients with neurological diseases.
Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia.
Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.
Autoimmune Encephalitides and Rapidly Progressive Dementias.
Primary age-related tauopathy (PART): a common pathology associated with human aging.
Dementia with Lewy bodies (DLB)
Research criteria for the diagnosis of prodromal dementia with Lewy bodies.
Frontotemporal dementia
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia.
Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine.
Primary Progressive aphasia (PPA)
Classification of primary progressive aphasia and its variants.
Vascular cognitive impairment
Cognitive deficit in Parkinson´s disease
Cognition Deficits in Parkinson's Disease: Mechanisms and Treatment.
Cognitive deficit in multiple system atrophy
Cognitive deficit in Corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP)
Cognition in corticobasal syndrome and progressive supranuclear palsy: a review.
Commentary
Fisher RS, Cross H, D'Souza C, French JA, Haut S, Higurashi N, Hirsch E, Jansen FE, Peltola J, Moshé SL, Perucca E, Lagae L, Roulet-Perez E, Schulze-Bonhage A, Scheffer IE, Somerville E, Sperling MR, Wiebe S, Yacubian EM, Zuberi S. 2017 International League Against Epilepsy classifications of seizures and epilepsy are steps in the right direction. Epilepsia 2019, Issue 60 (6), 1040-1044
Position Paper
Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, Hirsch E, Jain S, Mathern GW, Moshé SL, Nordli DR, Perucca E, Tomson T, Wiebe S, Zhang YH, Zuberi SM. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017, Issue 58 (4), 512-521.
Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Moshé SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017, Issue 58 (4), 522-530.
Trinka E, Cock H, Hesdorffer D, Rossetti AO, Scheffer IE, Shinnar S, Shorvon S, Lowenstein DH. A definition and classification of status epilepticus—Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia 2015, Issue 56 (10), 1515-23
Practice Guideline
Koutroumanidis M, Arzimanoglou A, Caraballo R, Goyal S, Kaminska A, Laoprasert P, Oguni H, Rubboli G, Tatum W, Thomas P, Trinka E, Vignatelli L, Moshé SL. The role of EEG in the diagnosis and classification of the epilepsy syndromes: a tool for clinical practice by the ILAE Neurophysiology Task Force (Part 1). Epileptic disorders 2017, 19(3), 233-298
Koutroumanidis M, Arzimanoglou A, Caraballo R, Goyal S, Kaminska A, Laoprasert P, Oguni H, Rubboli G, Tatum W, Thomas P, Trinka E, Vignatelli L, Moshé SL. The role of EEG in the diagnosis and classification of the epilepsy syndromes: a tool for clinical practice by the ILAE Neurophysiology Task Force (Part 2). Epileptic disorders 2017, 19(4), 385-437
Guideline
Tatum WO, Rubboli G, Kaplan PW, Mirsatari SM, Radhakrishnan K, Gloss D, Caboclo LO, Drislane FW, Koutroumanidis M, Schomer DL, Kasteleijn-Nolst Trenite D, Cook M, Beniczky S. Clinical utility of EEG in diagnosing and monitoring epilepsy in adults. Clin Neurophysiol. May;129(5), 1056-1082
Review
Mesraoua B, Deleu D, Kullmann DM, Shetty AK, Boon P, Perucca E, Mikati MA, Asadi-Pooya AA. Novel therapies for epilepsy in the pipeline. Epilepsy Behav. 2019 Aug;97:282-290
Perucca E, Brodie MJ, Kwan P, Tomson T. 30 years of second-generation antiseizure medications: impact and future perspectives. Lancet Neurol. VOLUME 19, ISSUE 6, P544-556, JUNE 01, 2020
Tomson T, Battino D, Perucca E. Teratogenicity of antiepileptic drugs. Curr Opin Neurol 2019 Apr;32(2):246-252
Beniczky S, Arbune AA, Jeppesen J, Ryvlin P. Biomarkers of seizure severity derived from wearable devices. Epilepsia 2020, Online first 10 June, 6-10
Löscher W, Potschka H, Sisodiya SM, Vezzani A. Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options. Pharmacol Rev. 2020, Jul; 72(3), 606-638.
Trinka E, Kälviäinen R. 25 years of advances in the definition, classification and treatment of status epilepticus. Seizure 2017, Jan; 44, 65-73
Systematic review
Boon P, De Cock E, Mertens A, Trinka E. Neurostimulation for drug-resistant epilepsy: a systematic review of clinical evidence for efficacy, safety, contraindications and predictors for response. Curr Opin Neurol, Apr;31(2), 198-210
Ferrari MD, Klever RR, Terwindt GM, Ayata C, van den Maagdenberg AM. Migraine pathophysiology: lessons from mouse models and human genetics. Lancet Neurol, 2015 Issue 14
Goadsby PJ, Holland PR, Martins-Oliveira M, Hoffmann J, Schankin C, Akerman S. Pathophysiology of Migraine: A Disorder of Sensory Processing. Physiol Rev 2017, Issue 97
Hoffmann J, May A. Diagnosis, pathophysiology, and management of cluster headache. Lancet Neurol 2018, Issue 17
Bendtsen L, Jensen R. Tension-type headache. Neurol Clin 2009, Issue 27
Steiner TJ, Stovner LJ, Vos T. GBD 2015: migraine is the third cause of disability in under 50s. J Headache Pain, 2016, Issue 17
Jensen R, Stovner LJ. Epidemiology and comorbidity of headache. Lancet Neurol 2008, Issue 7
Evers S, Marziniak M. Clinical features, pathophysiology, and treatment of medication-overuse headache. Lancet Neurol 2010, Issue 9
Zakrzewska JM, Linskey ME. Trigeminal neuralgia. BMJ 2015, Issue 350
Gelfand AA. Migraine and childhood periodic syndromes in children and adolescents. Curr Opin Neurol 2013, Issue 26
Antonaci F, Voiticovschi-Iosob C, Di Stefano AL, Galli F, Ozge A, Balottin U. The evolution of headache from childhood to adulthood: a review of the literature. J Headache Pain 2014, Issue 15
Kipps CM, Hodges JR. Cognitive assessment for cliniciansJournal of Neurology, Neurosurgery & Psychiatry 2005;76:i22-i30
PMID: 15718218
Zucchella C, Federico A, Martini A, et al. Neuropsychological testingPractical Neurology 2018;18:227-237, PMID: 29472384
Goldberg G Apraxia. Wiley Interdiscip Rev Cogn Sci. 2013; 4: 453-462
PMID: 26304239
Dovern, A., Fink, G.R. & Weiss, P.H. J Neurol (2012) 259: 1269.
PMID: 22215235
Rode G, Pagliari C, Huchon L, Rossetti Y, Pisella L. Semiology of neglect: An update. Annals of Physical and Rehabilitation Medicine. Volume 60, Issue 3, June 2017, Pages 177-185.
PMID: 27103056
Gainotti G, Trojano L. Constructional apraxia. Handbook of Clinical Neurology. 2018: 151; 331-348
PMID: 29519467
O'Sullivan M, Brownsett S, Copland DLanguage and language disorders: neuroscience to clinical practicePractical Neurology 2019;19:380-388
PMID: 31350297
Budson A, Price B. Primitive plaques and memory dysfunction in normal and impaired elderly persons. Practical Neurology. 2007: 7; 42-47
PMID: 17430864
Reid S, Thompson H, Thakur KT. Nervous System Infections and the Global Traveler. Semin Neurol. 2018;38(2):247-262. doi:10.1055/s-0038-1649335
Sigfrid L, Perfect C, Rojek A, et al. A systematic review of clinical guidelines on the management of acute, community-acquired CNS infections. BMC Med. 2019;17(1):170. Published 2019 Sep 6. doi:10.1186/s12916-019-1387-5
Thakur KT, Boubour A, Saylor D, Das M, Bearden DR, Birbeck GL. Global HIV neurology: a comprehensive review. AIDS. 2019;33(2):163-184. doi:10.1097/QAD.0000000000001796
Consensus review
Diagnosis: MDS clinical diagnostic criteria for Parkinson's disease.
Diagnosis: Phenomenology and classification of dystonia: a consensus update.
Guideline
EFNS/ENS Consensus on the diagnosis and management of chronic ataxias in adulthood.
Narrative review
Diagnosis, therapy: Neurogenic orthostatic hypotension and supine hypertension in Parkinson's disease and related synucleinopathies: prioritisation of treatment targets. https://www.ncbi.nlm.nih.gov/pubmed/25432722
Diagnosis, therapy: Atypical parkinsonism: diagnosis and treatment.
Diagnosis: Tremor entities and their classification: an update.
Diagnosis, therapy: Assessment of patients with isolated or combined dystonia: an update on dystonia syndromes.
Systematic review
Therapy, deep brain stimulation: Programming Deep Brain Stimulation for Parkinson's Disease: The Toronto Western Hospital Algorithms.
Pathophysiology, diagnosis, therapy: Multiple System Atrophy
Review
Congenital myopathies: clinical phenotypes and new diagnostic tools
The burden, epidemiology, costs and treatment for Duchenne muscular dystrophy: an evidence review
The Increasing Genetic and Phenotypical Diversity of Congenital Myasthenic Syndromes.
Antisense oligonucleotides: the next frontier for treatment of neurological disorders.
Genome engineering: a new approach to gene therapy for neuromuscular disorders.
GAD65 neurological autoimmunity.
Statin-Associated Autoimmune Myopathy: A Systematic Review of 100 Cases.
Metabolic myopathies: a practical approach.
A review of inflammatory idiopathic myopathy focusing on polymyositis.
Systematic review & modeling
Etiology: Global, regional & national risk factors
Diagnosis & prognosis: Disability-adjusted life years & life expectancy
Incidence, prevalence & YLDs: Incidence, prevalence & years lived with disability
Mortality with causes: Mortality, general & cause-specific
Review (Study methodology)
Descriptive studies: what they can and cannot do
Bias and causal associations in observational research
Cohort studies: marching towards outcomes
Case-control studies: research in reverse
Generation of allocation sequences in randomised trials: chance, not choice
Allocation concealment in randomised trials: defending against deciphering
Blinding in randomised trials: hiding who got what
Uses and abuses of screening tests
Unequal group sizes in randomised trials: guarding against guessing
Series (Study methodology)
Sample size calculations in randomised trials: mandatory and mystical
Compared to what? Finding controls for case-control studies
Refining clinical diagnosis with likelihood ratios.
Multiplicity in randomised trials I: endpoints and treatments
Multiplicity in randomised trials II: subgroup and interim analyses
Other (Study methodology)
The Good Clinical Practice guideline: a bronze standard for clinical research
Autoimmune Encephalitis
Dalmau J, Graus F. Antibody-Mediated Encephalitis. N Engl J Med. 2018 Mar1;378(9):840-851. doi: 10.1056/NEJMra1708712.
Hermetter C, Fazekas F, Hochmeister S. Systematic Review: Syndromes, Early Diagnosis, and Treatment in Autoimmune Encephalitis. Front Neurol. 2018 Sep5;9:706. doi: 10.3389/fneur.2018.00706.
Dalmau J, Armangué T, Planagumà J, Radosevic M, Mannara F, Leypoldt F, Geis C, Lancaster E, Titulaer MJ, Rosenfeld MR, Graus F. An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models. Lancet Neurol. 2019 Nov;18(11):1045-1057. doi: 10.1016/S1474-4422(19)30244-3.
van Sonderen A, Petit-Pedrol M, Dalmau J, Titulaer MJ. The value of LGI1, Caspr2 and voltage-gated potassium channel antibodies in encephalitis. Nat Rev Neurol. 2017 May;13(5):290-301. doi: 10.1038/nrneurol.2017.43.
Autoimmune Epilepsy
Vogrig A, Joubert B, André-Obadia N, Gigli GL, Rheims S, Honnorat J. Seizure specificities in patients with antibody-mediated autoimmune encephalitis. Epilepsia. 2019 Aug;60(8):1508-1525. doi: 10.1111/epi.16282.
MOG-Associated Syndromes
Reindl M, Waters P. Myelin oligodendrocyte glycoprotein antibodies in neurological disease. Nat Rev Neurol. 2019 Feb;15(2):89-102. doi:10.1038/s41582-018-0112-x.
Autoimmune Movement Disorders
Balint B, Vincent A, Meinck HM, Irani SR, Bhatia KP. Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology. Brain. 2018 Jan 1;141(1):13-36. doi: 10.1093/brain/awx189.
Immune Checkpoint Inhibitors (ICIs)-associated neurological complications
Graus F, Dalmau J. Paraneoplastic neurological syndromes in the era of immune-checkpoint inhibitors. Nat Rev Clin Oncol. 2019 Sep;16(9):535-548. doi:10.1038/s41571-019-0194-4.
Perrinjaquet C, Desbaillets N, Hottinger AF. Neurotoxicity associated with cancer immunotherapy: immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy. Curr Opin Neurol. 2019 Jun;32(3):500-510. doi:10.1097/WCO.0000000000000686.
Dalakas MC. Neurological complications of immune checkpoint inhibitors: what happens when you 'take the brakes off' the immune system. Ther Adv Neurol Disord. 2018 Sep14;11:1756286418799864. doi: 10.1177/1756286418799864.
Autoimmune Sleep Disorders
Bassetti CLA, Adamantidis A, Burdakov D, Han F, Gay S, Kallweit U, Khatami R, Koning F, Kornum BR, Lammers GJ, Liblau RS, Luppi PH, Mayer G, Pollmächer T, Sakurai T, Sallusto F, Scammell TE, Tafti M, Dauvilliers Y. Narcolepsy – clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nat Rev Neurol. 2019 Sep;15(9):519-539. doi: 10.1038/s41582-019-0226-9.
Barateau L, Dauvilliers Y. Recent advances in treatment for narcolepsy. Ther Adv Neurol Disord. 2019 Sep 26;12:1756286419875622. doi:10.1177/1756286419875622.
HLA in autoimmune neurological syndromes
Muñiz-Castrillo, S., Vogrig, A. & Honnorat, J. Associations between HLA and autoimmune neurological diseases with autoantibodies. Autoimmun Highlights 11, 2 (2020). https://doi.org/10.1186/s13317-019-0124-6
Multiple Sclerosis
Sastre-Garriga J, Pareto D, Battaglini M, Rocca MA, Ciccarelli O, Enzinger C, Wuerfel J, Sormani MP, Barkhof F, Yousry TA, De Stefano N, Tintoré M, Filippi M, Gasperini C, Kappos L, Río J, Frederiksen J, Palace J, Vrenken H, Montalban X, Rovira À; MAGNIMS study group. MAGNIMS consensus recommendations on the use of brain and spinal cord atrophy measures in clinical practice. Nat Rev Neurol. 2020 Feb 24. doi: 10.1038/s41582-020-0314-x.
Derfuss T, Mehling M, Papadopoulou A, Bar-Or A, Cohen JA, Kappos L. Advances in oral immunomodulating therapies in relapsing multiple sclerosis. Lancet Neurol. 2020 Feb 11. pii: S1474-4422(19)30391-6. doi:10.1016/S1474-4422(19)30391-6.
Ontaneda D, Tallantyre E, Kalincik T, Planchon SM, Evangelou N. Early highly effective versus escalation treatment approaches in relapsing multiple sclerosis. Lancet Neurol. 2019 Oct;18(10):973-980. doi: 10.1016/S1474-4422(19)30151-6.
CIDP
Alessandro L, Pastor Rueda JM, Wilken M, Querol L, Marrodán M, Acosta JN, Rivero A, Barroso F, Farez MF. Differences between acute-onset chronic inflammatory demyelinating polyneuropathy and acute inflammatory demyelinating polyneuropathy in adult patients. J Peripher Nerv Syst. 2018 Sep;23(3):154-158. doi: 10.1111/jns.12266.
Gut microbiota in neuroimmunology
Cryan JF, O'Riordan KJ, Sandhu K, Peterson V, Dinan TG. The gut microbiome in neurological disorders. Lancet Neurol. 2020 Feb;19(2):179-194. doi:10.1016/S1474-4422(19)30356-4.
Boziki MK, Kesidou E, Theotokis P, Mentis AA, Karafoulidou E, Melnikov V, Sviridova A, Rogovski V, Boyko A, Grigoriadis N. Microbiome in MS; where are we, what we know and do not know. Brain Science 2020 Apr 14; 10(4). pii: E234. doi: 10.3390/brainsci10040234
Meta-analysis
Review
Diagnosis, prognosis: The developing landscape of diagnostic and prognostic biomarkers for spinal cord injury in cerebrospinal fluid and blood.
Therapy: Fostering Poststroke Recovery: Towards Combination Treatments.
Assessment: Outcome Measures in Myasthenia Gravis: Incorporation Into Clinical Practice.
Systematic review
Therapy: Cognitive impairment in MS: rehabilitation approaches.
Therapy: Central and Peripheral Neural Targets for Neurostimulation of Chronic Headaches.
Consensus review: A consensus review on the development of palliative care for patients with chronic and progressive neurological disease.
Opinion: The role of palliative care in patients with neurological diseases
Review: End of life care in long term neurological conditions: a framework for implementation.
Cordonnier C et al. Intracerebral haemorrhage: current approaches to acute management. 2018 Lancet
PMID 30319113
Zerna C et al. Current practice and future directions in the diagnosis and acute treatment of ischaemic stroke. 2018 Lancet
PMID 30319112
Rodrigues FB et al. Endovascular treatment versus medical care alone for ischaemic stroke: systematic review and meta-analysis. 2016, BMJ
PMID 27091337
Wang Y et al. Acute dual antiplatelet therapy for minor ischaemic stroke or transient ischaemic attack. 2019, BMJ
PMID 30819687
Seiffge DJ et al. Timing of anticoagulation after recent ischaemic stroke in patients with atrial fibrillation. 2019, Lancet Neurology
PMID 30415934
Wardlaw JM et al. Small vessel disease: mechanisms and clinical implications. 2019, Lancet Neurology
PMID 31097385
Saver JL et al. Patent Foramen Ovale Closure Versus Medical Therapy for Cryptogenic Ischemic Stroke. 2018, Stoke
PMID 29760277
Orrapin S et al. Carotid endarterectomy for symptomatic carotid stenosis. 2017, Cochrane Database Syst Rev
PMID 28590505
Hart RG et al. Embolic Stroke of Undetermined Source: A Systematic Review and Clinical Update. 2017, Stroke
PMID 28265016
Ekker MS et al. Epidemiology, aetiology, and management of ischaemic stroke in young adults. 2018, Lancet Neurology
PMID 30129475