Knowledge Distillery

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| Interventional study with open label/non-randomised methodology  

Azithromycin for community treatment of suspected COVID-19 in people at increased risk of an adverse clinical course in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial

Azithromycin, an antibiotic with potential antiviral and anti-inflammatory properties, has been used to treat COVID-19, but evidence from community…

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Therapeutics

| Cross-sectional case-control studies  

Prevalence of mental disorders, suicidal ideation and suicides in the general population before and during the COVID-19 pandemic in Norway: A population-based repeated cross-sectional analysis

Self-report data on mental distress indicate a deterioration of population mental health in many countries during the COVID-19 pandemic.

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Impact on neurological comorbidities

| Interventional study with open label/non-randomised methodology  

Interleukin-6 receptor antagonists in critically ill patients with covid-19

The efficacy of interleukin-6 receptor antagonists in critically ill patients with COVID-19 is unclear. In this article the authors evaluated…

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Therapeutics

| Randomised double-blinded placebo-controlled trial  

Tocilizumab in hospitalized patients with severe COVID-19 pneumonia

COVID-19 is associated with immune dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of tocilizumab, a monoclonal…

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Therapeutics