Knowledge Distillery

The major complication of COVID-19 is hypoxaemic respiratory failure from capillary leak and alveolar oedema. Experimental and early clinical data…

SARS-CoV-2 entry in human cells depends on angiotensin-converting enzyme 2, which can be upregulated by inhibitors of the renin–angiotensin system…

COVID-19 is associated with a prothrombotic state leading to adverse clinical outcomes. Whether therapeutic anticoagulation improves outcomes in…

Evidence suggests a role for excessive inflammation in COVID-19 complications. Colchicine is an oral anti-inflammatory medication beneficial in gout,…

This is a Consensus Statement, which is introduced to provide a ten-step approach to the diagnosis and management of migraine.

The antibacterial, anti-inflammatory, and antiviral properties of azithromycin suggest therapeutic potential against COVID-19.

The emergence of highly transmissible SARS-CoV-2 variants of concern (VOC) that are resistant to therapeutic antibodies highlights the need for…

Most human monoclonal antibodies (mAbs) neutralizing SARS-CoV-2 recognize the spike (S) protein receptor-binding domain and block virus interactions…

SARS-CoV-2 has currently precipitated the COVID-19 global health crisis. The authors of this article developed a medium-throughput drug screening…

COVID-19 pandemic is the third zoonotic coronavirus (CoV) outbreak of the century after SARS in 2003 and MERS since 2012.

The objective of this article was to assess clinical outcomes with convalescent plasma treatment vs placebo or standard of care in peer-reviewed and…

Azithromycin, an antibiotic with potential antiviral and anti-inflammatory properties, has been used to treat COVID-19, but evidence from community…