Researchers analyzed data from two multicenter cohorts, comparing behavioral, cognitive, and neuroimaging features between genetic and sporadic bvFTD within each sex. Among women, those with sporadic bvFTD exhibited more pronounced compulsive behaviors and language impairments than those with genetic bvFTD. Conversely, females with genetic bvFTD showed greater gray matter loss, particularly in the parietal lobe. These findings suggest that women with sporadic bvFTD display a distinct clinical profile, which may contribute to underdiagnosis or misclassification of the disorder in females without genetic mutations.
Author(s):
Liu X. et al.
References including authors:
Liu X, de Boer SCM, Cortez K, Poos JM, Illán-Gala I, Heuer H, Forsberg LK, Casaletto K, Memel M, Appleby BS, Barmada S, Bozoki A, Clark D, Cobigo Y, Darby R, Dickerson BC, Domoto-Reilly K, Galasko DR, Geschwind DH, Ghoshal N, Graff-Radford NR, Grant IM, Hsiung GYR, Honig LS, Huey ED, Irwin D, Kantarci K, Léger GC, Litvan I, Mackenzie IR, Masdeu JC, Mendez MF, Onyike CU, Pascual B, Pressman P, Bayram E, Ramos EM, Roberson ED, Rogalski E, Bouzigues A, Russell LL, Foster PH, Ferry-Bolder E, Masellis M, van Swieten J, Jiskoot L, Seelaar H, Sánchez-Valle R, Laforce R, Graff C, ALLFTD Consortium & GENFI Consortium. Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia. Alzheimer’s Dement. 2025 Apr;21(4):e14608. doi:10.1002/alz.14608.