This study explored whether sex influences regional tau accumulation in clinically normal individuals, particularly in relation to β-amyloid (Aβ) and APOE ε4 status—key factors in Alzheimer disease (AD) progression. Researchers analyzed PET scan data from two cohorts, totaling 296 participants. While no consistent sex differences in regional tau were found across all brain areas, women showed higher tau levels in the entorhinal cortex than men, especially among those with elevated Aβ. No significant interaction between sex and APOE ε4 status was observed. These findings suggest that early tau buildup may begin earlier or progress more rapidly in women, supporting the notion of biological sex differences in AD risk and progression.
Author(s):
Rachel Buckley, Elizabeth Mormino, Jennifer Rabin et al.
References including authors:
Buckley RF, Mormino EC, Rabin JS, et al. Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults. JAMA Neurol. 2019;76(5):542–551. doi:10.1001/jamaneurol.2018.4693